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Project Summary | Project Information |
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3D bioprinting is a rapidly emerging field within tissue engineering. Such technology, useful for testing pharmaceuticals, conducting three-dimensional cell studies, and increasing transplant organ supplies and availability, allows for the growth of live cells within a biocompatible scaffold. Multiple materials, including hydrogels and bioink, must be printed in separate layers. Some layers require cross-linking in order to print complex and coherent designs. The current prototype is a third generation MSD project, and although it is able to print simple hydrogel structures, live cells have not been assimilated into the system. Furthermore, the nozzle often clogs and hydrogel extrusion is not automated. The goal of this project is to develop a fully automated demonstrational device that is capable of printing hydrogels as a solid matrix in precise, complex combinations. The biomaterial(s) selected for printing must have the ability to support cell growth and retain desired print shape. Furthermore, the device should be capable of incorporating multiple materials and the printing parameters should support the implementation of live cells. Additional improvements include automation of syringe pump control, proper mounting of the printhead, and testing various printing parameters. The customer has indicated a desired footprint for the model and that the printed product should not require any post-processing. Key constraints include utilizing the previous prototype and other materials supplied by our customer, maintaining cell viability, and creating a printer that can be transported to demonstrations. | Project Title: 3D Bioprinter Project Number: P21677 Start Term: Fall 2020 End Term: Spring 2021 Faculty Guide: John Wellin Primary Customer(s): Dr. Vinay Abhyankar |
Team Members
| Member | Major | Role | Contact |
|---|---|---|---|
| Diana Kulawiec | BME | Project Manager | dgk4073@rit.edu |
| Emma Kurz | BME | Facilitator | eck9451@rit.edu |
| Ramsey Doolittle | BME | Communications | rmd1608@rit.edu |
| Hayley Miller | BME | System Engineer - Bioprinting | hnm6892@rit.edu |
| Felix Chamberland | BME | System Engineer - Mechanical Support | fxc1578@rit.edu |
| Mark Truskinovsky | BME | System Engineer - Software, Purchasing | mxt6060@rit.edu |
Work Breakdown: By Phase
MSD I & II | MSD I | MSD II |
|---|---|---|
Integrated System Build & Test Customer Handoff & Final Project Documentation (Verification & Validation) |
Work Breakdown: By Topic
Project Management | Design Tools | Design Documentation | Presentation & Dissemination |
|---|---|---|---|
PRP Requirements Schedule Cost Risk Management Problem Management Communication & Minutes | Use Cases Benchmarking Functional Decomposition Morphological Chart Pugh Concept Selection | BOM Mechanical Drawings Electrical Schematics Software Diagrams Facility Layout Manuals | Design Review Documents Technical Paper Poster Imagine RIT Exhibit |
Acknowledgements
- Professor Vinay Abhyankar, PhD (RIT Biomedical Engineering) - Providing us the opportunity to work on this project by being our customer and providing invaluable resources, knowledge, and time to guide us through our work on this project.
- Professor John Wellin (RIT Mechanical Engineering) - Supporting our team as the project's faculty guide and showing the ropes of navigating through and succeeding in the MSD program.
- Nicholas Lee (Former RIT BME student, 2019-2020 3D Bioprinter project member, current Carnegie Mellon University BME PhD candidate) - Offering his time to provide our team some of his experiences and insight gained when working on the project.
- Daniel Reynolds, PhD (Harvard University Postdoctoral Fellow, Lewis Research Group) - Offering his time to provide our team with some knowledge and learning points from his experience with regenerative medicine and disease modeling.